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Certain polyphenolic compounds possess intrinsic diuretic properties that may exacerbate volume depletion or electrolyte derangements when combined with SGLT2 inhibitors

The early divergence of the MACE occurrence curves between the SEMA and placebo groups23 suggests that SEMA may have been directly involved in the SELECT study results through its effects on angiogenesis, reduction of oxidative stress and inflammation, and anti-atherogenic actions derived from GLP-1R activation that promote endothelial function and cell survival7 (Fig

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Release of sVEGFR1 provides a negative feedback loop of angiogenesis by sequestering VEGF-A and thereby preventing it from binding to VEGFRs (58)

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