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Clarification of the role of these channels in glutamate release will require the generation of conditional knockout mice, in which TREK1 or TWIK1 channels are removed specifically in astrocytes, thus providing a suitable system to assess their participation in neuroprotection or glutamate excitotoxicity (Heurteaux et al., 2004

Patient portals now routinely receive uploaded laboratory reports accompanied by questions such as: "My cholesterol is slightly elevatedshould I start medication?" "My thyroid test is abnormal

Lane CJ, Redding DR, Gonzalez KA, Cardenas VJ, Boldogh I, Sur S

Collectively, these observations indicate that we are only scratching the surface in our understanding of NAD + metabolism

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