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With aging, multiple structural and functional alterations such as decreased cerebrovascular pulsatility, reduced aquaporin-4 polarization on astrocyte end feet, and impaired perivascular cerebrospinal fluid exchange significantly reduce glymphatic efficiency

Emerging research suggests probiotics may support digestive health and immune function while indirectly supporting liver health, although more canine-specific studies are needed

erinaceus on the quality of murine gut microbiota and found a change in the relative abundance of different bacteria depending on the age of the mice used for the microbiota analysis

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In metabolic disease, nutrient overload and ER stress elevate H 2 O 2 /O 2 , coupling lipotoxicity to ferroptotic risk when labile iron expands (Schieber and Chandel 2014)