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, 93 , 185-198, Jiang, Q., and Hurst, J

J.ChenQ.PrzybelskiS

5 Conclusion and future perspectives Changes in metabolism play a crucial role in shaping the extent and nature of T cell differentiation and function, with a metabolically hostile TME often leading to infiltrated T cell dysfunction, which seems to be the most prominent roadblock in CAR-T cell therapy against solid tumors