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Indeed, direct tests revealed a lack of input specificity of synaptic changes in CA1 inhibitory neurons (McMahon and Kauer, Thus, initial studies demonstrate that CA1 interneurons can express long-term synaptic plasticity, which is calcium-dependent (Cowan et al., 2001) but not input-specific (McMahon and Kauer, 2+ imaging has demonstrated that synaptically induced rises of [Ca 2+ ] i in aspiny dendrites do not spread much but are kept local by interneuron-specific mechanisms (Goldberg et al., Box 1 and below in the sections on calcium signals and heterosynaptic plasticity

Additional risk factors included older age, high blood pressure, smoking, and the use of aspirin

425,426 Additionally, IgG, IgM, and IgA autoantibodies against HSP60, HSP70, and HSP90 are significantly elevated in RA patients

doi: 10.3389/fpsyg.2025.1641693 Received 06 June 2025 Accepted 19 August 2025 Published 09 September 2025 Volume 16 - 2025 Edited by Mark Antoniou, Western Sydney University, Australia Reviewed by Alexandra Wolf, RIKEN Center for Advanced Intelligence Project (AIP), Japan Lifeng Tang, Ningbo Rehabilitation Hospital, China Updates Copyright 2025 Maggio, Maione, Cotelli, Bonasera, Corallo, Pistorino, Luca, Marra, Quartarone, Nicoletti and Calabr

The thioredoxin system in cancer