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However, the extent to which aminotransferases contribute to glutamate biosynthesis in intact cells is limited by the transport rates for the various substrates

(Source 3) 6

Gastrointestinal Disorders : Individuals with conditions that affect nutrient absorption, such as Crohns disease, celiac disease, or those who have had surgeries like gastric bypass, may benefit from B12 shots due to impaired absorption of vitamins from the diet

Cell type-selective secretome profiling in vivo

That variety matters because it allows treatment to be tailored to the individual rather than forcing every patient into the same approach