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A recent clinical study demonstrated that cognitively unimpaired individuals carrying the APOE 4 allele exhibited early BBB breakdown in the hippocampus and medial temporal lobe compared to non-carriers, with even greater BBB permeability observed in APOE 4 carriers who showed signs of cognitive impairment [122]

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Although marked spectral changes were detected in the hyperfine splitting constants of EBN/ SG upon its inclusion in CDs, resolved signals from the free and bound nitroxide were not obtained, and hence we did not assess the constants of the corresponding inclusion complexes

Other advances have been realized by rational optimization of bNAb epitopes, resulting in increases in the breadth and potency of NAb responses elicited after immunization 23

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