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Metabolites altered in ME/CFS patients include a decrease of myo-inositol, a putative marker of glial dysfunction (Noda et al., 2018), in the anterior cingulate cortex (Godlewska et al., 2021), and an increase of choline mainly found in glial cells and thought to indicate an increased cell membrane turnover notably due to reparative gliosis in the left anterior cingulate (Mueller et al., 2020) and basal ganglia (Tanaka et al., 2006

Other methods, for example in situ brain perfusion technique, allow determination of the Cl in , which is based on evaluation of the unidirectional transfer constant ( K in ) and permeability surface area product (PS product)

Ado-Trastuzumab Emtansine

Cheng X, Fan K, Wang L, et al

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