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Trials conducted between 2001 and 2007 demonstrated statistically significant reductions in body fat, although the larger Phase IIb OPTIONS trial did not replicate these findings at sufficient magnitude for regulatory approval, and formal development was discontinued in 2007

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Avoid repeated freeze-thaw cycles and keep materials in their original sealed container until ready for use

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Clinicians administering the combination have not reported any adverse interaction effects beyond the individual side effects of each compound