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Flavonoids can be summarized to reverse MDR via multiple mechanisms such as regulating the ABC transporters, boosting ROS production in cancer cells, or conversely inhibiting the activities of the anti-oxidative enzymes, subduing the proliferation of cancer stem cells, inhibiting EMT (epithelialmesenchymal transition) signalling, modulating autophagy and the related factors, and lastly, by distorting the progression of cell cycle in cancer cells [202]

Carriers of an MTHFR variant, who have elevated homocysteine, are running low-grade NMDA excitotoxicity continuously

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