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This in turn leads to excessive free radical formation

Osteoarthritis Cartilage 22:17741783 Buckwalter JA, Mankin HJ (1998) Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation

A meta-analysis published in Sleep Medicine Reviews indicates that individuals who experience chronic sleep deprivation are at a higher risk for developing conditions such as obesity, diabetes, and cardiovascular diseases

Excitation-inhibition imbalance leads to alteration of neuronal coherence and neurovascular coupling under acute stress

However, the authors suggest that cyto-therapy may be more appropriate for patients with more severe conditions (150)