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In contrast, T2 low asthma may involve neutrophilic or pauci-granulocytic inflammation with cytokines, such as IL-6, IL-8, IL-17 and tumor necrosis factor alpha (TNF-), playing key roles in neutrophil recruitment and chronic inflammation

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Newer delivery methods under development include GLP-1 transdermal patches , which would bypass injection entirely, and oral tirzepatide formulations