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The Emerging Role of Central and Peripheral Immune Systems in Neurodegenerative Diseases

Positions 2 and 4 of the motif are crucial for the association of FFAT motif-containing proteins with VAPs (Di Mattia et al, 2020a

doi: 10.3389/fmolb.2025.1710944 Received 22 September 2025 Accepted 09 October 2025 Published 29 October 2025 Volume 12 - 2025 Edited by Giuseppe Valacchi, North Carolina State University, United States Reviewed by Enrique Cadenas, University of Southern California, United States Updates Copyright 2025 Dang, Liou, Mullah and Giulivi

CD38 serves as the primary degrading enzyme for nicotinamide adenine dinucleotide (NAD) in mammalian cells, an essential endogenous antioxidant in mammals