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17 American College of Obstetricians and Gynecologists

Eur J Clin Invest 29:238245

[8] (Patients in long-term remission should only be considered for therapy on a case-by-case basis in consultation with an oncologist.) Intracranial Lesions: Sermorelin is not recommended for patients whose GH deficiency is caused by an intracranial tumor or lesion

When combined with other substances, treatment can become more complicated

A meta-analysis published in 2023 that included this trial and four other treatment trials conducted since that time concluded that duloxetine is only associated with a modest trend toward pain reduction and that this is accompanied by a similar trend in increased adverse events, suggesting a need for additional well-designed trials to support its continued use in this setting (Chow 2023)