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SIRT5 represses neurotrophic pathways and Abeta production in Alzheimers disease by targeting autophagy

FASN regulation is complex, involving the activation of multiple signaling pathways such as PI3K/Akt/mammalian target of rapamycin (mTOR), Wnt/-catenin, mitogen-activated protein kinase, epidermal growth factor receptor, and SREBP, along with post-translational modifications like ubiquitination, acetylation, and SUMOylation [73,74,75,76,77]