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In order to produce a pharmacological effect, a drug needs to cross the bloodbrain barrier (BBB) in sufficient concentration and interact with a target within the brain

The severity of schizophrenia depends in part on oxidative stress and the level of neurochemical imbalance affecting neural circuits in several brain structures such as the hippocampus, prefrontal cortex, and striatum (18, 57)

They are simply maintaining exogenous testosterone rather than cycling on and off

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Activated STAT3 was higher expressed in the mice with 5-HT when compared with mice lack of 5-HT, which hinted that 5-HT might promote liver regeneration partially by the activation of STAT3