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Shen, E

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Second, the cross-sectional nature of the study limits our ability to establish causality and exclude the potential reverse causation between biomarkers and diseases, highlighting the need for larger interventional studies

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To assess the efficacy of combination treatment, tumour-bearing mice were treated as above with 5FU + metformin and CC3-quantified, showing an increase in average cell death per tumour per mouse with combination treatment (Extended Data Fig