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These include dietary changes and herbal supplements that may help manage the symptoms and progression of this condition

Indoxyl sulfate inhibits nitric oxide production and induces reactive oxygen species production, gradually damaging endothelial cell layer (Tumur and Niwa 2009)

Moreover, peripheral pathology seen in CIPN can lead to maladaptive responses in the brain that contribute to CIPN even if chemotherapy drugs do not enter the brain, as we discuss below