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BNIP3, a member of the pro-apoptotic protein family, is upregulated in response to hypoxic conditions and has been implicated in the induction of autophagic cell death (93)

The usual clinical course for people so treated is to have initially improved glycemic control but over time a need for intensification of drug-based treatment of hyperglycemia

If supplementation is deemed advisable due to inadequate Se intake, organic Se in the form of SeMet is preferable to inorganic Se, as the former binds to proteins and is retained more efficiently [22]

Koullarnda S, Deaminaze A, Bakteriler , Bitki T, Edilmesi GT, akmak R (2009) Promotion of plant growth by ACC deaminase-producing plant growth promoting bacteria under stress conditions

Additionally, ROS upregulate the expression of the immune checkpoint PD-L1, further strengthening TAM-mediated immunosuppression [147, 149]