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In dogs, it is usually secondary to gastrointestinal hemorrhage secondary to bleeding ulcers or tumors or colonic ectasia (Harvey et al 1982, Fan et al., 1999)

While dysfunctions within monoaminergic neurotransmitter systems are likely to play an important role in pathophysiology of mood disorders, it probably represents the downstream effects of more primary abnormalities in signal transduction

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Trunk blood samples were drawn and liver and kidney tissue samples were taken on day 10