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These included adrenoleukodystrophy/Adreno myeloneuropathy (n=4/1), CSF1Rleukoencephalopathy (n=4), Cockayne syndrome (n=4), cerebrotendinous xanthomatosis (n=4), CADASIL (n=3), methylmalonic acidemia with homocystinuria (n=3), hereditary spastic paraplegia type 82 (n=2), megalencephalic leukoencephalopathy (n=2) and one each related to mutations in CLCN2 , Metachromatic leukodystrophy, MTHFR , PelizaeusMerzbacher disease, DKC1 , FAHN, IBA57 related, Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation (LBSL), TMEM63A , ABCA7 , and PSEN1

This raises intracellular calcium levels, triggering smooth muscle contraction

Regardless of therapy, relapse is common and shortens the survival of leukemia patients

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Lei Z, Tian D, Zhang C, et al