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Microglia and astrocytes fractal analysis was performed as described ( Supplementary Figure 2 ): colorized images ( Supplementary Figure 2a ) were transformed to 8-bit grayscale to best visualize all positive staining ( Supplementary Figure 2b )

Wahl S, Engelhardt M, Schaupp P, Lappe C, Ivanov IV

Smythe, The Conquest of Arid America (New York: Harper and Brothers, 1900), 238

They can be loaded with chemotherapeutic agents, gene therapy vectors, or photothermal and photodynamic therapy (PDT) agents, effectively inducing tumor cell destruction