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Excluded from these guidelines because of insufficient European experience, or of tangential relationship with UCDs are: citrin deficiency (citrullinemia type 2, MIM #605814 and #603471), lysinuric protein intolerance (LPI, MIM #222700), deficiencies of pyrroline 5-carboxylate synthetase (MIM #610652) and ornithine aminotransferase deficiency (OAT, MIM #258870), despite the fact that they may cause hyperammonemia

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Translation of these regenerative and network-based therapies into clinical practice will require careful calibration

In hepatocellular carcinoma, the knockout of OC2 using the CRISPR/Cas9 system not only significantly inhibits the proliferation and angiogenesis of hepatocellular carcinoma cells but also markedly promotes apoptosis