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In the hyperglycemic clamping experiment, cotadutide was also found to reduce the de novo fat production of the liver during clamping

Uricosuric agents like dotinurad enhance UA excretion by targeting specific enzymes involved in purine metabolism

Under oxidative stress, excessive ROS such as OH directly attack DNA, causing single-strand or double-strand breaks, activating PARP-1, consuming NAD and ATP, and generating poly(ADP-ribose), resulting in mitochondrial membrane potential loss and the release of apoptosis-inducing factor, ultimately resulting in cell death [252]

[167] Healthcare providers should counsel patients and caregivers about the importance of secure medication storage and the potential risks associated with accidental pediatric exposure

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