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Neumann, M

administered AAV serotype 8-mediated gene therapy, derived by cloning hABCB4 cDNA into a modified AAV expression cassette, as a single dose to ABCB4 knockout mice and found restoration of biliary phospholipid excretion with normalization of plasma alkaline phosphatase and bilirubin

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This provides an important theoretical basis for studying the interaction between mitochondrial dysfunction and diabetic ketoacidosis and may have implications for developing new treatment strategies targeting DKA