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1C), the methyltransferase that was also significantly elevated in SSc skin biopsies 24

The mitochondrial workload MOTS-c creates will exhaust available NAD+ faster than baseline metabolism, reducing the magnitude and duration of AMPK's effects

Imaging confirmation: Procedure note states fluoroscopy or CT guidance was used

WADA Prohibition The World Anti-Doping Agency explicitly prohibits AOD-9604 for competitive athletes: Listed under Section S0 (Non-Approved Substances) and S2.2.3 (Growth Hormone Fragments) Prohibited at all times (both in-competition and out-of-competition) No Therapeutic Use Exemptions (TUEs) available Detection methods developed and implemented in anti-doping laboratories worldwide WADAs 2013 statement clarified that AOD-9604 is a substance still under pre-clinical and clinical development and has not been approved for therapeutic use by any government health authority in the world. Research Classification: AOD-9604 is available only for laboratory research use

AOD-9604 produced no statistically significant weight loss in its only completed efficacy trial