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[DOI] [PMC free article] [PubMed] [Google Scholar] 8.Biswas P., Dellanoce C., Vezzoli A., Mrakic-Sposta S., Malnati M., Beretta A., Accinni R

393 Studies indicate that a lack of SIRT6 leads to reduced mitochondrial gene expression, increased production of ROS, and accelerated mitochondrial decay, collectively triggering mitochondrial dysfunction

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On the other hand, after HR development antioxidant activities and levels of GSH, increased significantly (Fodor et al., 1997)