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Circadian misalignment, particularly of the sleep-wake cycle, has been implicated in the pathophysiology of neurodegenerative disorders such as Alzheimers, Parkinsons, and Huntingtons diseases, acting not only as a clinical manifestation but also as an active driver of disease progression (Videnovic and Zee, 2015

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Theyre relatively accurate, but generally not as sensitive as more sophisticated lab testing methods

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Yanai H, Ito K, Yoshida H, Tada N (2008) Antihypertensive effects of astaxanthin