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Trends in Glycoscience and Glycotechnology, 30 , SJ11SJ24

Conclusions Based on the available evidence, the primary drivers of IR are metabolic disturbances in insulin-responsive tissues (liver, skeletal muscle, and adipose tissue) and impaired insulin production by -cells at the stage of T2DM

nci Turkoglu, orcid.org/0000-0001-8401-962X

& Borgdorff, M

Furthermore, RNF12 N-terminal sequences suppress chromatin recruitment and substrate ubiquitylation, uncovering a previously unappreciated autoinhibitory mechanism