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The remarkable plasticity of microglial cells allows them to adapt and respond to their microenvironment, contributing to immune surveillance, neuroinflammation, tissue repair, and synaptic remodeling

One significant contribution was made by Hyman Zimmerman in the 1960s, who observed that patients exhibiting hepatocellular DILI alongside jaundice had a notably elevated risk (between 10 and 50%) of progressing to acute liver failureduring a time when liver transplantation was not yet an option

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Elevated levels of activated c-Abl have been observed in brain tissues of patients with PD, suggesting that c-Abl inhibitors may hold therapeutic potential for PD

It can suppress tumor growth by eliminating cells with impaired antioxidant capacity, particularly in contexts of chemoresistance or metastasis