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doi: 10.1016/j.cmet.2020.12.011 96 KwonSYParkYJ

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However, in atretic follicles, FSH may activate autophagy via different signaling pathways, leading to granulosa cells degradation and triggering follicular atresia ( Overall, the role of autophagy in establishing the follicular pool and promoting follicular survival highlights its potential as a novel therapeutic target for addressing DOR in vulnerable populations, such as those exposed to chemotherapy, environmental toxins, or genetic disorders (Figure 3B)