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Description

EMBO J (2010) 29:333043

Fatal infantile cardioencephalomyopathy with COX deficiency and mutations in SCO2, a COX assembly gene

Specifically, flavokavain A (20 M) suppressed the expression of the pro-inflammatory iNOS and COX-2, as well as the subsequent production of NO, PGE-2 and pro-inflammatory cytokines such as TNF-, IL-1 and IL-6