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the subacute stage, which relies upon the release of the inflammatory mediators

J Agric Food Chem 70(4):11631173

Hyaluronan is the main component of the ECM, and its precursor is synthesized by the HBP, and L-DON inhibits glutamine-fructose aminotransferase 1 (GFPT1), the rate-limiting enzyme in the HBP, resulting in decreased hyaluronan synthesis, affecting the mechanical properties of the ECM in the TME and enhancing the infiltration of CD8 + T cells and the anti-tumor immune response [120]