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Leukemia 35(12):3421-3429, 2021

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Changes in certain growth factors trigger PI3K activation, such as loss of phosphatase and tensin homolog (PTEN), or increased expression of epidermal growth factor receptor (EGFR)

Case-fatality rates for RMSF were as high as 6580% prior to antibiotics 3 and can be fatal even after antibiotic treatment 4

Th-2-31 plasma stability test Hamsters were randomized into 3 injection groups and treated with a single dose of Th-2-31 at 10 mg/kg through intravenous injection ( n = 6) or at 20 mg/kg through intraperitoneal injection ( n = 6) or oral administration ( n = 6)