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However, it has been recently described that mTORC2 also possesses tyrosine phosphorylation capacity [118], and that it phosphorylates tyrosines on IRS and tyrosine kinases in both receptors, IGF-1 and IR, thus reinstituting the signal of the activated receptors [118]

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Serum copper levels in HCC patients are significantly higher than in the chronic hepatitis control group (137 24 vs 107 15 g/dl, p = 0.0030) (119, 168)