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Phenotype enrichment analysis also revealed that genes downregulated by NAC are involved in oxidative and toxic metal stress resistance, suggesting that SKN-1, an ortholog of the mammalian master regulator of oxidative stress defense, NRF-2, is negatively regulated by NAC (Supplementary Fig

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10.3390/antiox12101885 24 KimuraI.IchimuraA.Ohue-KitanoR.IgarashiM