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Indeed, an intrinsic problem with siRNA is that it acts as a Toll-like receptor 3 (TLR3) ligand, and lipid nanoparticle (LNP) formulations cause additional stimulation by cationic lipids of LNP 33,41,42

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Some common conditions include neuralgia of the arm, intercostal and sciatic neuralgia, pain in the limbs, herpes zoster, and even restless leg syndrome