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Eight weeks of treatment with 100 mg Pycnogenol per day not only reduced menopausal symptoms but also improved cardiovascular risk profiles by lowering high blood pressure as well as cholesterol, triglyceride, blood glucose, homocysteine, CRP, and free radical levels in 35 postmenopausal women, while no such changes were seen in 35 matched controls

In one animal model, when compared to platelet-derived growth factor, after eight days it was roughly equivalent (2)

Moreover, GSNO at this concentration was non-toxic to HUVECs, the first cells exposed to GSNO-derived NO during retrograde perfusion, supporting its safety and endothelial tolerance in this experimental setting

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of papilloma in each group as shown in Fig