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On the one hand, many scholars have proposed to change the composition and molecular structure of SOD by chemical modification, point mutation, liposome modification, and microencapsulation [101,102,103,104] without changing its biological activity so as to improve its stability [105]

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The flies solely administered with L-DOPA performed better during initial exposure after which their progress declined, consistent with the reported pattern of wearing-off in L-DOPA administered PD patients 39,55

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