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111 Understanding how genetic and epigenetic, neurologic, hormonal, and immune mechanisms contribute to the experience of pain may help patients reconceptualize their condition, feel less anxious, and feel more empowered to make changes that can improve their outcomes

Chronic structural damage like advanced arthritis, complete tears, bone spurs, and disc herniations typically show minimal response

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As environmental leachates they lead to increased water and soil pollution, as well as to serious harm to human health

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