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While early literature suggested that p53-dependent tumor suppression involved the induction of cell cycle arrest, senescence or apoptosis, the recent analysis of several transactivation-defective p53 mutants has called this model into question and it now appears that alterations in intracellular metabolism may account for the ability of p53 to suppress tumor formation [6870]

doi: 10.1007/s13238-017-0451-1 27 PatraKCHayN

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These findings informed human PET studies using the HDAC tracer [11C] Martinostat, which confirmed elevated HDAC expression in the brains of chronic drinkers

"A little bit goes a long way tooonly a few pumps cover my arms and legs," our tester attested