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Wang and Xiong, 2013)

Abbreviations AD: Alzheimer disease A: Amyloid beta CI: Confidence interval DSM: Diagnostic and Statistical Manual of Mental Disorders DTBN: 5,5-Dithio-bis(2-nitrobenzoic acid) GSH: Glutathione HC: Healthy control MCI: Mild cognitive impairment MEGA-PRESS: Meshcher-Garwood Point-Resolved Spectroscopy MMSE: Mini-Mental State Examination MRS: Magnetic resonance spectroscopy OPA: O-Phthalaldehyde OS: Oxidative stress PRESS: Point resolved spectroscopy SMD: Standardized mean difference STEAM: STimulated Echo Acquisition Mode References Koyama A, O'Brien J, Weuve J, Blacker D, Metti AL, Yaffe K

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In some embodiments, the active ingredient portion of a composition of the disclosure comprises about 45 % to about 55 % of antioxidant (e.g

Apoptosis in CD is regulated via both intrinsic (e.g., Bcl-2 family, mitochondrial ROS/JNK) and extrinsic (e.g., TNF-/TNFR) pathways, with network-like dysregulation involving molecules like Runx2, VPS4B, circSMAD4, and MPST