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The development of drug resistance has been documented in several regions globally, due to the overuse of PZQ, rate of parasitic mutation, poor treatment compliance, co-infection with different strains of schistosomes and the overall parasite load

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Kobayashi A et al., Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

But because Rifaximin on its own has low success for methane SIBO and we dont want to permanently damage the gut with Neomycin, antibiotics definitely arent our preference for first line treatment

Their inhibition slows connective tissue breakdown and helps maintain smoother, firmer skin