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In a different study, the impact of methotrexate was evaluated in a Swiss mouse skin tumor model methylcholanthrene (MCA)

Mitochondrial membrane potential The mitochondrial membrane potential ( m ) was assessed with MitoProbe DilC 1 (5) (Life Technologies) (50 nM) by flow cytometry (FACScalibur flow cytometer, BD Biosciences) and expressed in arbitrary units

This significantly alters the energy characteristics of cardiac chambers, resulting in impaired cardiac function

they are also a well-described finding in paraneoplastic DM