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Lee MN, Kang B, Choi SY, Kim MJ, Woo SY, Kim JW et al

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Recently, Chen and colleagues developed a SAD cortical organoid model from human iPSCs and exposed it to serum to mimic BBB breakage, a common AD feature, and observed increased A-like pathology, hyperphosphorylated tau, synaptic loss, and an impaired neural network [191]

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PEGylation extends circulation half-life and reduces protein adsorption, yet anti-PEG antibodies can emergepromoting complement activation and rapid clearancewhich necessitates monitoring and the exploration of alternative stealth coatings (Ju et al., 2023