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Using CRP reduction as evidence of autoimmune treatment efficacy is a logical error that conflates general inflammation with disease-specific immune dysregulation

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Treatment resulted in reduced MBL, but the effect was considered small (standardized mean differences 1.11, 95% CI 1.38 to 0.83) and in higher rates of amenorrhoea (2.9% in the placebo group vs 23.7% to 96.1% in the SPRM group)

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Adv Therapeutics 8(1):2400250 Krinsky NI, Landrum JT, Bone RA (2003) Biologic mechanisms of the protective role