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In gastric and colorectal cancer, high CHAC2 expression leads to reduced glutathione, elevated intracellular Ca 2+ and increased ROS, resulting in inhibited tumor growth, proliferation and migration

J Cosmet Dermatol 19:34083413

Therefore, in response to iron accumulation and high levels of ROS within AT, certain anti-inflammatory immune cells may also be affected by the ferroptosis process, resulting in their inability to neutralize the inflammatory response caused by pro-inflammatory cytokines in a timely manner

Liraglutide also induction HO-1 expression by activating AMPK and promoting HIF-1 protein export from cytoplasm to nucleus, which significantly increases the expression of anti-apoptotic protein Bcl-2 and decreases the expression of pro-apoptotic Bax and Caspase-3 in HUVECs cells [134]

10.1016/j.gene.2015.09.030 62 YousefiF.ShabaninejadZ.VakiliS.DerakhshanM.MovahedpourA.DabiriH.et al (2020)