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doi:10.1186/s12970-015-0067-x Bellanti F, Coda ARD, Trecca MI, Lo Buglio A, Serviddio G, Vendemiale G

71 Interestingly, metabolite profiling of cells treated with Cu ionophore presents a time-dependent increase in the dysregulation of many TCA cycle-associated metabolites, and inhibiting the electron transport chain complexes I and II significantly reduced Cu-induced cell death