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Bioinformatic analysis was performed, using MEG4.0 Neighbour-Joining method for phylogenetic tree construction, using Stand-alone BLAST (download from for alignment of the three gene clusters ( alp , flu and lom ), and using the net-based National Center for Biotechnology Information Conserved Domain Search Service for deduction of protein functions

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This revision represented a paradigm shift, acknowledging the conditions multifactorial etiology, which encompassed factors such as viral infections and immune system dysfunction [20]

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3.1.2 -amyloid (A) and tau proteins A accumulation in multiple brain regions and hyperphosphorylation of tau proteins are also pathological alterations in PD, resulting in neuroprogenitor fibril tangles (Wills et al., 2010)