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Kobe J Med Sci (2018) 64(3):E10714

Targeting key regulators in glutamine metabolism, such as glutaminases and glutamine transporters, prompts the discovery of druggable targets and promising anti-cancer drug candidates (Fig

In addition, itaconate was investigated for its role as an anti-inflammatory and antioxidant metabolite of the TCA cycle [124]

Similar content being viewed by others Introduction Liver cancer, primarily HCC, is among the most challenging tumors to treat, ranking sixth globally in incidence and third in cancer-related deaths